8V9D

Structure of human AQP4 with a pathogenic autoantibody - rAB 186

Summary for 8V9D

• Entry DOI: 10.2210/pdb8v9d/pdb
• EMDB information: 43071
• Descriptor: Aquaporin-4, rAB 186 Heavy Chain, rAB 186 Light Chain, ... (4 entities in total)
• Functional Keywords: aquaporin, water-channel, transport protein-immune system complex, neuromyelitis optica (nmo), autoimmnune disease, transport protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 295825.14

Authors

Gupta, M.,Khandelwal, N.K.,Stroud, R.M. (deposition date: 2023-12-07, release date: 2024-12-11, Last modification date: 2025-06-04)

• Primary citation: Gupta, M.,Khandelwal, N.K.,Stroud, R.M.; Human AQP4 structure in lipid nanodisc using cryo-EM; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.9 Å)