8V9D

Structure of human AQP4 with a pathogenic autoantibody - rAB 186

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, B, C, D)	Aquaporin-4	polymer	348	37982.9	4	UniProt (P55087) Pfam (PF00230)	Homo sapiens (human)
2	B, E, H (I, K, M)	rAB 186 Heavy Chain	polymer	233	24642.6	3		Homo sapiens (human)
3	C, F, I (J, L, N)	rAB 186 Light Chain	polymer	215	23321.9	3		Homo sapiens (human)
4	K, L, M, N (A, B, C, D)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 323 (UniProt: P55087)

PDB	External Database	Details
Met -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Lys -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	295825.1
All*	Total formula weight	295825.1

*Water molecules are not included.