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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8V9D

Structure of human AQP4 with a pathogenic autoantibody - rAB 186

Functional Information from GO Data
ChainGOidnamespacecontents
A0003091biological_processrenal water homeostasis
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0009897cellular_componentexternal side of plasma membrane
A0009992biological_processintracellular water homeostasis
A0010008cellular_componentendosome membrane
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0030054cellular_componentcell junction
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0050891biological_processmulticellular organismal-level water homeostasis
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0071346biological_processcellular response to type II interferon
A0090660biological_processcerebrospinal fluid circulation
A0097450cellular_componentastrocyte end-foot
B0003091biological_processrenal water homeostasis
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0009897cellular_componentexternal side of plasma membrane
B0009992biological_processintracellular water homeostasis
B0010008cellular_componentendosome membrane
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0030054cellular_componentcell junction
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0050891biological_processmulticellular organismal-level water homeostasis
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0071346biological_processcellular response to type II interferon
B0090660biological_processcerebrospinal fluid circulation
B0097450cellular_componentastrocyte end-foot
C0003091biological_processrenal water homeostasis
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0009897cellular_componentexternal side of plasma membrane
C0009992biological_processintracellular water homeostasis
C0010008cellular_componentendosome membrane
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0030054cellular_componentcell junction
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0050891biological_processmulticellular organismal-level water homeostasis
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0071346biological_processcellular response to type II interferon
C0090660biological_processcerebrospinal fluid circulation
C0097450cellular_componentastrocyte end-foot
D0003091biological_processrenal water homeostasis
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0009897cellular_componentexternal side of plasma membrane
D0009992biological_processintracellular water homeostasis
D0010008cellular_componentendosome membrane
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0030054cellular_componentcell junction
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0050891biological_processmulticellular organismal-level water homeostasis
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0071346biological_processcellular response to type II interferon
D0090660biological_processcerebrospinal fluid circulation
D0097450cellular_componentastrocyte end-foot
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HINPAVTVA
ChainResidueDetails
AHIS95-ALA103
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
JTYR193-HIS199
ITYR206-HIS212
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues476
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues156
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues92
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsIntramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsMotif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsMotif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P55088","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P47863","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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