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8V9D

Structure of human AQP4 with a pathogenic autoantibody - rAB 186

Functional Information from GO Data
ChainGOidnamespacecontents
A0003091biological_processrenal water homeostasis
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0009897cellular_componentexternal side of plasma membrane
A0009992biological_processintracellular water homeostasis
A0010008cellular_componentendosome membrane
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0050891biological_processmulticellular organismal-level water homeostasis
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0071346biological_processcellular response to type II interferon
A0090660biological_processcerebrospinal fluid circulation
A0097450cellular_componentastrocyte end-foot
B0003091biological_processrenal water homeostasis
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0009897cellular_componentexternal side of plasma membrane
B0009992biological_processintracellular water homeostasis
B0010008cellular_componentendosome membrane
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0050891biological_processmulticellular organismal-level water homeostasis
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0071346biological_processcellular response to type II interferon
B0090660biological_processcerebrospinal fluid circulation
B0097450cellular_componentastrocyte end-foot
C0003091biological_processrenal water homeostasis
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0009897cellular_componentexternal side of plasma membrane
C0009992biological_processintracellular water homeostasis
C0010008cellular_componentendosome membrane
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0050891biological_processmulticellular organismal-level water homeostasis
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0071346biological_processcellular response to type II interferon
C0090660biological_processcerebrospinal fluid circulation
C0097450cellular_componentastrocyte end-foot
D0003091biological_processrenal water homeostasis
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0009897cellular_componentexternal side of plasma membrane
D0009992biological_processintracellular water homeostasis
D0010008cellular_componentendosome membrane
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0050891biological_processmulticellular organismal-level water homeostasis
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0071346biological_processcellular response to type II interferon
D0090660biological_processcerebrospinal fluid circulation
D0097450cellular_componentastrocyte end-foot
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HINPAVTVA
ChainResidueDetails
AHIS95-ALA103

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
JTYR193-HIS199
ITYR206-HIS212

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues512
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:19383790
ChainResidueDetails
AMET1-LYS36
BCYS253-VAL323
CMET1-LYS36
CHIS90-GLY93
CVAL102-SER115
CSER177-ASP184
CCYS253-VAL323
DMET1-LYS36
DHIS90-GLY93
DVAL102-SER115
DSER177-ASP184
AHIS90-GLY93
DCYS253-VAL323
AVAL102-SER115
ASER177-ASP184
ACYS253-VAL323
BMET1-LYS36
BHIS90-GLY93
BVAL102-SER115
BSER177-ASP184

site_idSWS_FT_FI2
Number of Residues476
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:19383790
ChainResidueDetails
AALA37-ILE57
BALA156-ALA176
BVAL185-ILE205
BILE232-PHE252
CALA37-ILE57
CMET70-GLY89
CVAL116-VAL136
CALA156-ALA176
CVAL185-ILE205
CILE232-PHE252
DALA37-ILE57
AMET70-GLY89
DMET70-GLY89
DVAL116-VAL136
DALA156-ALA176
DVAL185-ILE205
DILE232-PHE252
AVAL116-VAL136
AALA156-ALA176
AVAL185-ILE205
AILE232-PHE252
BALA37-ILE57
BMET70-GLY89
BVAL116-VAL136

site_idSWS_FT_FI3
Number of Residues156
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:19383790
ChainResidueDetails
AASN58-ASP69
CTHR137-THR155
CASN206-THR208
CILE223-TRP231
DASN58-ASP69
DTHR137-THR155
DASN206-THR208
DILE223-TRP231
ATHR137-THR155
AASN206-THR208
AILE223-TRP231
BASN58-ASP69
BTHR137-THR155
BASN206-THR208
BILE223-TRP231
CASN58-ASP69

site_idSWS_FT_FI4
Number of Residues80
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:19383790
ChainResidueDetails
AGLY94-THR101
AGLY209-VAL222
BGLY94-THR101
BGLY209-VAL222
CGLY94-THR101
CGLY209-VAL222
DGLY94-THR101
DGLY209-VAL222

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P55088
ChainResidueDetails
ASER111
BSER111
CSER111
DSER111

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P47863
ChainResidueDetails
ASER180
BSER180
CSER180
DSER180

site_idSWS_FT_FI7
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47863
ChainResidueDetails
ASER276
ASER321
BSER276
BSER321
CSER276
CSER321
DSER276
DSER321

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55088
ChainResidueDetails
ASER285
BSER285
CSER285
DSER285

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55088
ChainResidueDetails
ATHR289
BTHR289
CTHR289
DTHR289

site_idSWS_FT_FI10
Number of Residues8
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P47863
ChainResidueDetails
ACYS13
ACYS17
BCYS13
BCYS17
CCYS13
CCYS17
DCYS13
DCYS17

site_idSWS_FT_FI11
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN153
AASN206
BASN153
BASN206
CASN153
CASN206
DASN153
DASN206

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PDB entries from 2025-05-28

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