8UWC
Site-one protease without SPRING
Summary for 8UWC
| Entry DOI | 10.2210/pdb8uwc/pdb |
| EMDB information | 42661 |
| Descriptor | Membrane-bound transcription factor site-1 protease, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | serine protease cholesterol metabolism zymogen activation protein complex glycoprotein secretory pathway, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 114105.00 |
| Authors | Kober, D.L. (deposition date: 2023-11-06, release date: 2024-07-10, Last modification date: 2024-07-24) |
| Primary citation | Hendrix, S.,Dartigue, V.,Hall, H.,Bawaria, S.,Kingma, J.,Bajaj, B.,Zelcer, N.,Kober, D.L. SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain. Nat Commun, 15:5732-5732, 2024 Cited by PubMed: 38977690DOI: 10.1038/s41467-024-50068-8 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.27 Å) |
Structure validation
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