8UWC

Site-one protease without SPRING

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005795	cellular_component	Golgi stack
A	0006508	biological_process	proteolysis
A	0006606	biological_process	protein import into nucleus
A	0006607	biological_process	NLS-bearing protein import into nucleus
A	0006629	biological_process	lipid metabolic process
A	0007040	biological_process	lysosome organization
A	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0030968	biological_process	endoplasmic reticulum unfolded protein response
A	0031293	biological_process	membrane protein intracellular domain proteolysis
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0036500	biological_process	ATF6-mediated unfolded protein response
A	0045540	biological_process	regulation of cholesterol biosynthetic process
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0051604	biological_process	protein maturation
A	0060627	biological_process	regulation of vesicle-mediated transport

Functional Information from PROSITE/UniProt

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTfVAGvIAS

Chain	Residue	Details
A	HIS249-SER259

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site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSvAsPvVAG

Chain	Residue	Details
A	GLY412-GLY422

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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