8UVM

SARS-CoV-2 papain-like protease (PLpro) complex with covalent inhibitor Jun11313

Summary for 8UVM

Entry DOI	10.2210/pdb8uvm/pdb
Descriptor	Papain-like protease nsp3, ethyl 4-oxo-4-(2-{3-[2-({(1S)-1-[(3P)-3-(thiophen-3-yl)phenyl]ethyl}carbamoyl)phenyl]propanoyl}hydrazinyl)butanoate, SULFATE ION, ... (6 entities in total)
Functional Keywords	sars cov-2 papain like protease complex, covalent inhibitor, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus)
Total number of polymer chains	4
Total formula weight	146684.71
Authors	Ansari, A.,Tan, B.,Chopra, A.,Ruiz, F.X.,Arnold, E.,Wang, J. (deposition date: 2023-11-03, release date: 2024-04-03, Last modification date: 2024-05-01)
Primary citation	Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383:1434-1440, 2024 Cited by PubMed: 38547259 DOI: 10.1126/science.adm9724 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation