8UVM
SARS-CoV-2 papain-like protease (PLpro) complex with covalent inhibitor Jun11313
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Papain-like protease nsp3 | polymer | 318 | 35943.8 | 4 | UniProt (P0DTD1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 2019-nCoV COVID-19 virus) | Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO |
| 2 | E, I, M, Q (A, B, C, D) | ethyl 4-oxo-4-(2-{3-[2-({(1S)-1-[(3P)-3-(thiophen-3-yl)phenyl]ethyl}carbamoyl)phenyl]propanoyl}hydrazinyl)butanoate | non-polymer | 521.6 | 4 | Chemie (Y3R) | |||
| 3 | F, J, N, R (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, K, O, S, T (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | H, L, P, U (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 315 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143775.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2909.7 | |
| All* | Total formula weight | 146684.7 |
