8U18

Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo

8U18 の概要

• エントリーDOI: 10.2210/pdb8u18/pdb
• EMDBエントリー: 41805
• 分子名称: Thrombopoietin receptor,GCN4 isoform 1, Thrombopoietin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: receptor, cytokine, signalling, haematopoiesis, cytokine-receptor complex, cytokine/receptor
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135149.25

構造登録者

Sarson-Lawrence, K.S.,Hardy, J.M.,Leis, A.,Babon, J.J.,Kershaw, N.J. (登録日: 2023-08-30, 公開日: 2024-02-07, 最終更新日: 2024-02-21)

• 主引用文献: Sarson-Lawrence, K.T.G.,Hardy, J.M.,Iaria, J.,Stockwell, D.,Behrens, K.,Saiyed, T.,Tan, C.,Jebeli, L.,Scott, N.E.,Dite, T.A.,Nicola, N.A.,Leis, A.P.,Babon, J.J.,Kershaw, N.J.; Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.; Nat Commun, 15:1135-1135, 2024; PubMed: 38326297; DOI: 10.1038/s41467-024-45356-2

実験手法

ELECTRON MICROSCOPY (3.6 Å)