8TRV

Structure of the EphA2 LBDCRD bound to FabS1C_C1

8TRV の概要

• エントリーDOI: 10.2210/pdb8trv/pdb
• 関連するPDBエントリー: 8TRS 8TRT 8TRV
• 分子名称: Ephrin type-A receptor 2, S1C variant of Fab_C1 heavy chain, S1C variant of Fab_C1 light chain, ... (7 entities in total)
• 機能のキーワード: cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 163542.76

構造登録者

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (登録日: 2023-08-10, 公開日: 2024-07-17)

• 主引用文献: Adams, J.J.,Bruce, H.A.,Ploder, L.,Garcia, J.,Khutoreskaya, G.,Jarvik, N.,Costa, L.E.,Gorelik, M.,Pot, I.,Sicheri, F.,Blazer, L.L.,Singer, A.U.,Sidhu, S.S.; Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation; To be Published,

実験手法

X-RAY DIFFRACTION (3.25 Å)