8T7R

Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07

Summary for 8T7R

• Entry DOI: 10.2210/pdb8t7r/pdb
• Descriptor: Light chain from antibody JTK191b E07, Fab heavy chain from antibody JTK191b E07, MHC class I antigen (Fragment), ... (5 entities in total)
• Functional Keywords: human leukocyte antigen, hla, hla class i, antibodies, autoimmunity, fab, alloreactive, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 50
• Total formula weight: 972578.05

Authors

Green, T.J.,Killian Jr, J.T.,Qiu, S.,Macon, K.J.,Yang, G.,King, R.G.,Lund, F.E. (deposition date: 2023-06-21, release date: 2024-12-25)

• Primary citation: Killian Jr, J.T.,King, R.G.,Kizziah, J.L.,Fucile, C.F.,Diaz-Avalos, R.,Qiu, S.,Silva-Sanchez, A.,Mousseau, B.J.,Macon, K.J.,Callahan, A.R.,Yang, G.,Hossain, E.M.,Akther, J.,Good, D.B.,Kelso, S.,Houp, J.A.,Rosenblum, F.,Porrett, P.M.,Ong, S.C.,Kumar, V.,Ollmann Saphire, E.,Kearney, J.F.,Randall, T.D.,Rosenberg, A.F.,Green, T.J.,Lund, F.E.; B cell and antibody targeting of transplant alloantigen epitopes is supported by both self and allo-recognition; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.84 Å)