8T7R

Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010038	biological_process	response to metal ion
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0033077	biological_process	T cell differentiation in thymus
D	0033572	biological_process	transferrin transport
D	0034756	biological_process	regulation of iron ion transport
D	0034757	biological_process	negative regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0048261	biological_process	negative regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002376	biological_process	immune system process
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010038	biological_process	response to metal ion
H	0010977	biological_process	negative regulation of neuron projection development
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0033077	biological_process	T cell differentiation in thymus
H	0033572	biological_process	transferrin transport
H	0034756	biological_process	regulation of iron ion transport
H	0034757	biological_process	negative regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0048261	biological_process	negative regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002376	biological_process	immune system process
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010038	biological_process	response to metal ion
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0033077	biological_process	T cell differentiation in thymus
L	0033572	biological_process	transferrin transport
L	0034756	biological_process	regulation of iron ion transport
L	0034757	biological_process	negative regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0048261	biological_process	negative regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0000139	cellular_component	Golgi membrane
P	0001913	biological_process	T cell mediated cytotoxicity
P	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
P	0002237	biological_process	response to molecule of bacterial origin
P	0002376	biological_process	immune system process
P	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
P	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
P	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
P	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
P	0002726	biological_process	positive regulation of T cell cytokine production
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005765	cellular_component	lysosomal membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005788	cellular_component	endoplasmic reticulum lumen
P	0005794	cellular_component	Golgi apparatus
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0007608	biological_process	sensory perception of smell
P	0007611	biological_process	learning or memory
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010038	biological_process	response to metal ion
P	0010977	biological_process	negative regulation of neuron projection development
P	0012507	cellular_component	ER to Golgi transport vesicle membrane
P	0016020	cellular_component	membrane
P	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
P	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
P	0023026	molecular_function	MHC class II protein complex binding
P	0030670	cellular_component	phagocytic vesicle membrane
P	0031901	cellular_component	early endosome membrane
P	0031902	cellular_component	late endosome membrane
P	0031905	cellular_component	early endosome lumen
P	0033077	biological_process	T cell differentiation in thymus
P	0033572	biological_process	transferrin transport
P	0034756	biological_process	regulation of iron ion transport
P	0034757	biological_process	negative regulation of iron ion transport
P	0035580	cellular_component	specific granule lumen
P	0042026	biological_process	protein refolding
P	0042605	molecular_function	peptide antigen binding
P	0042612	cellular_component	MHC class I protein complex
P	0042613	cellular_component	MHC class II protein complex
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0042824	cellular_component	MHC class I peptide loading complex
P	0045646	biological_process	regulation of erythrocyte differentiation
P	0048260	biological_process	positive regulation of receptor-mediated endocytosis
P	0048261	biological_process	negative regulation of receptor-mediated endocytosis
P	0050680	biological_process	negative regulation of epithelial cell proliferation
P	0050768	biological_process	negative regulation of neurogenesis
P	0050778	biological_process	positive regulation of immune response
P	0050870	biological_process	positive regulation of T cell activation
P	0051289	biological_process	protein homotetramerization
P	0055038	cellular_component	recycling endosome membrane
P	0060586	biological_process	multicellular organismal-level iron ion homeostasis
P	0070062	cellular_component	extracellular exosome
P	0071281	biological_process	cellular response to iron ion
P	0071283	biological_process	cellular response to iron(III) ion
P	0071316	biological_process	cellular response to nicotine
P	1904724	cellular_component	tertiary granule lumen
P	1990000	biological_process	amyloid fibril formation
P	1990712	cellular_component	HFE-transferrin receptor complex
P	2000774	biological_process	positive regulation of cellular senescence
P	2000978	biological_process	negative regulation of forebrain neuron differentiation
T	0000139	cellular_component	Golgi membrane
T	0001913	biological_process	T cell mediated cytotoxicity
T	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
T	0002237	biological_process	response to molecule of bacterial origin
T	0002376	biological_process	immune system process
T	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
T	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
T	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
T	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
T	0002726	biological_process	positive regulation of T cell cytokine production
T	0005198	molecular_function	structural molecule activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005765	cellular_component	lysosomal membrane
T	0005783	cellular_component	endoplasmic reticulum
T	0005788	cellular_component	endoplasmic reticulum lumen
T	0005794	cellular_component	Golgi apparatus
T	0005829	cellular_component	cytosol
T	0005886	cellular_component	plasma membrane
T	0005925	cellular_component	focal adhesion
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0007608	biological_process	sensory perception of smell
T	0007611	biological_process	learning or memory
T	0009897	cellular_component	external side of plasma membrane
T	0009986	cellular_component	cell surface
T	0010038	biological_process	response to metal ion
T	0010977	biological_process	negative regulation of neuron projection development
T	0012507	cellular_component	ER to Golgi transport vesicle membrane
T	0016020	cellular_component	membrane
T	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
T	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
T	0023026	molecular_function	MHC class II protein complex binding
T	0030670	cellular_component	phagocytic vesicle membrane
T	0031901	cellular_component	early endosome membrane
T	0031902	cellular_component	late endosome membrane
T	0031905	cellular_component	early endosome lumen
T	0033077	biological_process	T cell differentiation in thymus
T	0033572	biological_process	transferrin transport
T	0034756	biological_process	regulation of iron ion transport
T	0034757	biological_process	negative regulation of iron ion transport
T	0035580	cellular_component	specific granule lumen
T	0042026	biological_process	protein refolding
T	0042605	molecular_function	peptide antigen binding
T	0042612	cellular_component	MHC class I protein complex
T	0042613	cellular_component	MHC class II protein complex
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0042824	cellular_component	MHC class I peptide loading complex
T	0045646	biological_process	regulation of erythrocyte differentiation
T	0048260	biological_process	positive regulation of receptor-mediated endocytosis
T	0048261	biological_process	negative regulation of receptor-mediated endocytosis
T	0050680	biological_process	negative regulation of epithelial cell proliferation
T	0050768	biological_process	negative regulation of neurogenesis
T	0050778	biological_process	positive regulation of immune response
T	0050870	biological_process	positive regulation of T cell activation
T	0051289	biological_process	protein homotetramerization
T	0055038	cellular_component	recycling endosome membrane
T	0060586	biological_process	multicellular organismal-level iron ion homeostasis
T	0070062	cellular_component	extracellular exosome
T	0071281	biological_process	cellular response to iron ion
T	0071283	biological_process	cellular response to iron(III) ion
T	0071316	biological_process	cellular response to nicotine
T	1904724	cellular_component	tertiary granule lumen
T	1990000	biological_process	amyloid fibril formation
T	1990712	cellular_component	HFE-transferrin receptor complex
T	2000774	biological_process	positive regulation of cellular senescence
T	2000978	biological_process	negative regulation of forebrain neuron differentiation
X	0000139	cellular_component	Golgi membrane
X	0001913	biological_process	T cell mediated cytotoxicity
X	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
X	0002237	biological_process	response to molecule of bacterial origin
X	0002376	biological_process	immune system process
X	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
X	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
X	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
X	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
X	0002726	biological_process	positive regulation of T cell cytokine production
X	0005198	molecular_function	structural molecule activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005765	cellular_component	lysosomal membrane
X	0005783	cellular_component	endoplasmic reticulum
X	0005788	cellular_component	endoplasmic reticulum lumen
X	0005794	cellular_component	Golgi apparatus
X	0005829	cellular_component	cytosol
X	0005886	cellular_component	plasma membrane
X	0005925	cellular_component	focal adhesion
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006955	biological_process	immune response
X	0007608	biological_process	sensory perception of smell
X	0007611	biological_process	learning or memory
X	0009897	cellular_component	external side of plasma membrane
X	0009986	cellular_component	cell surface
X	0010038	biological_process	response to metal ion
X	0010977	biological_process	negative regulation of neuron projection development
X	0012507	cellular_component	ER to Golgi transport vesicle membrane
X	0016020	cellular_component	membrane
X	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
X	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
X	0023026	molecular_function	MHC class II protein complex binding
X	0030670	cellular_component	phagocytic vesicle membrane
X	0031901	cellular_component	early endosome membrane
X	0031902	cellular_component	late endosome membrane
X	0031905	cellular_component	early endosome lumen
X	0033077	biological_process	T cell differentiation in thymus
X	0033572	biological_process	transferrin transport
X	0034756	biological_process	regulation of iron ion transport
X	0034757	biological_process	negative regulation of iron ion transport
X	0035580	cellular_component	specific granule lumen
X	0042026	biological_process	protein refolding
X	0042605	molecular_function	peptide antigen binding
X	0042612	cellular_component	MHC class I protein complex
X	0042613	cellular_component	MHC class II protein complex
X	0042802	molecular_function	identical protein binding
X	0042803	molecular_function	protein homodimerization activity
X	0042824	cellular_component	MHC class I peptide loading complex
X	0045646	biological_process	regulation of erythrocyte differentiation
X	0048260	biological_process	positive regulation of receptor-mediated endocytosis
X	0048261	biological_process	negative regulation of receptor-mediated endocytosis
X	0050680	biological_process	negative regulation of epithelial cell proliferation
X	0050768	biological_process	negative regulation of neurogenesis
X	0050778	biological_process	positive regulation of immune response
X	0050870	biological_process	positive regulation of T cell activation
X	0051289	biological_process	protein homotetramerization
X	0055038	cellular_component	recycling endosome membrane
X	0060586	biological_process	multicellular organismal-level iron ion homeostasis
X	0070062	cellular_component	extracellular exosome
X	0071281	biological_process	cellular response to iron ion
X	0071283	biological_process	cellular response to iron(III) ion
X	0071316	biological_process	cellular response to nicotine
X	1904724	cellular_component	tertiary granule lumen
X	1990000	biological_process	amyloid fibril formation
X	1990712	cellular_component	HFE-transferrin receptor complex
X	2000774	biological_process	positive regulation of cellular senescence
X	2000978	biological_process	negative regulation of forebrain neuron differentiation
b	0000139	cellular_component	Golgi membrane
b	0001913	biological_process	T cell mediated cytotoxicity
b	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
b	0002237	biological_process	response to molecule of bacterial origin
b	0002376	biological_process	immune system process
b	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
b	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
b	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
b	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
b	0002726	biological_process	positive regulation of T cell cytokine production
b	0005198	molecular_function	structural molecule activity
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005615	cellular_component	extracellular space
b	0005765	cellular_component	lysosomal membrane
b	0005783	cellular_component	endoplasmic reticulum
b	0005788	cellular_component	endoplasmic reticulum lumen
b	0005794	cellular_component	Golgi apparatus
b	0005829	cellular_component	cytosol
b	0005886	cellular_component	plasma membrane
b	0005925	cellular_component	focal adhesion
b	0006826	biological_process	iron ion transport
b	0006879	biological_process	intracellular iron ion homeostasis
b	0006955	biological_process	immune response
b	0007608	biological_process	sensory perception of smell
b	0007611	biological_process	learning or memory
b	0009897	cellular_component	external side of plasma membrane
b	0009986	cellular_component	cell surface
b	0010038	biological_process	response to metal ion
b	0010977	biological_process	negative regulation of neuron projection development
b	0012507	cellular_component	ER to Golgi transport vesicle membrane
b	0016020	cellular_component	membrane
b	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
b	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
b	0023026	molecular_function	MHC class II protein complex binding
b	0030670	cellular_component	phagocytic vesicle membrane
b	0031901	cellular_component	early endosome membrane
b	0031902	cellular_component	late endosome membrane
b	0031905	cellular_component	early endosome lumen
b	0033077	biological_process	T cell differentiation in thymus
b	0033572	biological_process	transferrin transport
b	0034756	biological_process	regulation of iron ion transport
b	0034757	biological_process	negative regulation of iron ion transport
b	0035580	cellular_component	specific granule lumen
b	0042026	biological_process	protein refolding
b	0042605	molecular_function	peptide antigen binding
b	0042612	cellular_component	MHC class I protein complex
b	0042613	cellular_component	MHC class II protein complex
b	0042802	molecular_function	identical protein binding
b	0042803	molecular_function	protein homodimerization activity
b	0042824	cellular_component	MHC class I peptide loading complex
b	0045646	biological_process	regulation of erythrocyte differentiation
b	0048260	biological_process	positive regulation of receptor-mediated endocytosis
b	0048261	biological_process	negative regulation of receptor-mediated endocytosis
b	0050680	biological_process	negative regulation of epithelial cell proliferation
b	0050768	biological_process	negative regulation of neurogenesis
b	0050778	biological_process	positive regulation of immune response
b	0050870	biological_process	positive regulation of T cell activation
b	0051289	biological_process	protein homotetramerization
b	0055038	cellular_component	recycling endosome membrane
b	0060586	biological_process	multicellular organismal-level iron ion homeostasis
b	0070062	cellular_component	extracellular exosome
b	0071281	biological_process	cellular response to iron ion
b	0071283	biological_process	cellular response to iron(III) ion
b	0071316	biological_process	cellular response to nicotine
b	1904724	cellular_component	tertiary granule lumen
b	1990000	biological_process	amyloid fibril formation
b	1990712	cellular_component	HFE-transferrin receptor complex
b	2000774	biological_process	positive regulation of cellular senescence
b	2000978	biological_process	negative regulation of forebrain neuron differentiation
f	0000139	cellular_component	Golgi membrane
f	0001913	biological_process	T cell mediated cytotoxicity
f	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
f	0002237	biological_process	response to molecule of bacterial origin
f	0002376	biological_process	immune system process
f	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
f	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
f	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
f	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
f	0002726	biological_process	positive regulation of T cell cytokine production
f	0005198	molecular_function	structural molecule activity
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005615	cellular_component	extracellular space
f	0005765	cellular_component	lysosomal membrane
f	0005783	cellular_component	endoplasmic reticulum
f	0005788	cellular_component	endoplasmic reticulum lumen
f	0005794	cellular_component	Golgi apparatus
f	0005829	cellular_component	cytosol
f	0005886	cellular_component	plasma membrane
f	0005925	cellular_component	focal adhesion
f	0006826	biological_process	iron ion transport
f	0006879	biological_process	intracellular iron ion homeostasis
f	0006955	biological_process	immune response
f	0007608	biological_process	sensory perception of smell
f	0007611	biological_process	learning or memory
f	0009897	cellular_component	external side of plasma membrane
f	0009986	cellular_component	cell surface
f	0010038	biological_process	response to metal ion
f	0010977	biological_process	negative regulation of neuron projection development
f	0012507	cellular_component	ER to Golgi transport vesicle membrane
f	0016020	cellular_component	membrane
f	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
f	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
f	0023026	molecular_function	MHC class II protein complex binding
f	0030670	cellular_component	phagocytic vesicle membrane
f	0031901	cellular_component	early endosome membrane
f	0031902	cellular_component	late endosome membrane
f	0031905	cellular_component	early endosome lumen
f	0033077	biological_process	T cell differentiation in thymus
f	0033572	biological_process	transferrin transport
f	0034756	biological_process	regulation of iron ion transport
f	0034757	biological_process	negative regulation of iron ion transport
f	0035580	cellular_component	specific granule lumen
f	0042026	biological_process	protein refolding
f	0042605	molecular_function	peptide antigen binding
f	0042612	cellular_component	MHC class I protein complex
f	0042613	cellular_component	MHC class II protein complex
f	0042802	molecular_function	identical protein binding
f	0042803	molecular_function	protein homodimerization activity
f	0042824	cellular_component	MHC class I peptide loading complex
f	0045646	biological_process	regulation of erythrocyte differentiation
f	0048260	biological_process	positive regulation of receptor-mediated endocytosis
f	0048261	biological_process	negative regulation of receptor-mediated endocytosis
f	0050680	biological_process	negative regulation of epithelial cell proliferation
f	0050768	biological_process	negative regulation of neurogenesis
f	0050778	biological_process	positive regulation of immune response
f	0050870	biological_process	positive regulation of T cell activation
f	0051289	biological_process	protein homotetramerization
f	0055038	cellular_component	recycling endosome membrane
f	0060586	biological_process	multicellular organismal-level iron ion homeostasis
f	0070062	cellular_component	extracellular exosome
f	0071281	biological_process	cellular response to iron ion
f	0071283	biological_process	cellular response to iron(III) ion
f	0071316	biological_process	cellular response to nicotine
f	1904724	cellular_component	tertiary granule lumen
f	1990000	biological_process	amyloid fibril formation
f	1990712	cellular_component	HFE-transferrin receptor complex
f	2000774	biological_process	positive regulation of cellular senescence
f	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
W	TYR257-HIS263
A	TYR193-HIS199
V	TYR205-HIS211
X	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	704
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---