8T75

Crystal Structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD-CRD)

8T75 の概要

• エントリーDOI: 10.2210/pdb8t75/pdb
• 分子名称: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: kras, ras, raf1, craf, oncoprotein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 147967.53

構造登録者

Whitley, M.J.,Simanshu, D.K. (登録日: 2023-06-19, 公開日: 2024-02-14, 最終更新日: 2024-02-28)

• 主引用文献: Whitley, M.J.,Tran, T.H.,Rigby, M.,Yi, M.,Dharmaiah, S.,Waybright, T.J.,Ramakrishnan, N.,Perkins, S.,Taylor, T.,Messing, S.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Turbyville, T.,Cornilescu, G.,Simanshu, D.K.; Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.; Sci Adv, 10:eadj4137-eadj4137, 2024; PubMed: 38354232; DOI: 10.1126/sciadv.adj4137

実験手法

X-RAY DIFFRACTION (2.65 Å)