8T68

Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 in complex with RQ3-111

Summary for 8T68

Entry DOI	10.2210/pdb8t68/pdb
Descriptor	Histone-lysine N-methyltransferase KMT5B, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	set domain, methyltransferase, sgc, suv420h1, transport protein, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32481.88
Authors	Zeng, H.,Dong, A.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-15, release date: 2024-11-27)
Primary citation	Zeng, H.,Dong, A.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 in complex with RQ3-111. To be published,
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation