8T4M
Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Summary for 8T4M
Entry DOI | 10.2210/pdb8t4m/pdb |
Related | 5U6P |
EMDB information | 41036 41040 41041 |
Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total) |
Functional Keywords | ion channel, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 396804.10 |
Authors | Burtscher, V.,Mount, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Yuan, P.,Chanda, B. (deposition date: 2023-06-09, release date: 2024-06-12, Last modification date: 2024-07-03) |
Primary citation | Burtscher, V.,Mount, J.,Huang, J.,Cowgill, J.,Chang, Y.,Bickel, K.,Chen, J.,Yuan, P.,Chanda, B. Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15:5216-5216, 2024 Cited by PubMed: 38890331DOI: 10.1038/s41467-024-49599-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.16 Å) |
Structure validation
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