8SVE
Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR
Summary for 8SVE
Entry DOI | 10.2210/pdb8sve/pdb |
Descriptor | Fab Heavy chain, Interleukin-10,Fab light chain, ACETATE ION, ... (5 entities in total) |
Functional Keywords | antibody cytokine graft, engineered protein, immune regulatory cytokine, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 133413.33 |
Authors | |
Primary citation | DiDonato, M.,Spraggon, G.,Simpson, C.T.,Vo, M.T.,Knuth, M.,Geierstanger, B.,Jamontt, J.,Fathman, J.J.,DeLarosa, D.,Junt, T.,Picard, D.,Sommer, U.,Vogel, B.,Bagger, M.,Peters, E.,Meeusen, S. A Novel Interleukin-10 Antibody Graft to Treat Inflammatory Bowel Disease. To Be Published, |
Experimental method |
Structure validation
Download full validation report