8SJ0

Structure of ternary complex of cGAS with dsDNA and bound 2'-dATP

Summary for 8SJ0

• Entry DOI: 10.2210/pdb8sj0/pdb
• Descriptor: Cyclic GMP-AMP synthase, Palindromic DNA18, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: immune system, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 108500.71

Authors

Wu, S.,Sohn, J. (deposition date: 2023-04-17, release date: 2024-04-24, Last modification date: 2024-05-29)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.; Nat Commun, 15:4012-4012, 2024; PubMed: 38740774; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.55 Å)