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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8SJ0

Structure of ternary complex of cGAS with dsDNA and bound 2'-dATP

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues82
DetailsRegion: {"description":"Interaction with collided ribosomes","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues10
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LEZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsSite: {"description":"Arginine-anchor","evidences":[{"source":"PubMed","id":"31808743","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsSite: {"description":"Cleavage; by CASP3","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"39322678","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"PubMed","id":"26829768","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CDK1 and PKB","evidences":[{"source":"PubMed","id":"26440888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32351706","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl glutamate","evidences":[{"source":"PubMed","id":"26829768","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32474700","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"35210392","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues6
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32457395","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32457395","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"29426904","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"28095500","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38418882","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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