8SDG

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.43

Summary for 8SDG

• Entry DOI: 10.2210/pdb8sdg/pdb
• Descriptor: Neutralizing antibody CC25.43 heavy chain, Neutralizing antibody CC25.43 light chain, Spike protein S1, ... (4 entities in total)
• Functional Keywords: sars-cov-2, coronavirus, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 141625.26

Authors

Yuan, M.,Wilson, I.A. (deposition date: 2023-04-06, release date: 2024-03-13, Last modification date: 2025-07-16)

• Primary citation: Song, G.,Yuan, M.,Liu, H.,Capozzola, T.,Lin, R.N.,Torres, J.L.,He, W.T.,Musharrafieh, R.,Dueker, K.,Zhou, P.,Callaghan, S.,Mishra, N.,Yong, P.,Anzanello, F.,Avillion, G.,Vo, A.L.,Li, X.,Zhang, Y.,Makhdoomi, M.,Feng, Z.,Zhu, X.,Peng, L.,Nemazee, D.,Safonova, Y.,Briney, B.,Ward, A.B.,Burton, D.R.,Wilson, I.A.,Andrabi, R.; Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift; Cell Rep, 44:115948-, 2025; DOI: 10.1016/j.celrep.2025.115948

Experimental method

X-RAY DIFFRACTION (2.71 Å)