8RQC
Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2
Summary for 8RQC
Entry DOI | 10.2210/pdb8rqc/pdb |
Descriptor | Protein cereblon, DNA-binding protein Ikaros, ZINC ION, ... (5 entities in total) |
Functional Keywords | e3 ligase, protac, tpd, molecular glue, targeted protein degradation, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 84393.69 |
Authors | Furihata, H.,Kroupova, A.,Zollman, D.,Ciulli, A. (deposition date: 2024-01-17, release date: 2024-09-25) |
Primary citation | Kroupova, A.,Spiteri, V.,Furihata, H.,Darren, D.,Ramachandran, S.,Rutter, Z.,Chakraborti, S.,Haubrich, K.,Pethe, J.,Gonzales, D.,Wijaya, A.,Rodriguez-Rios, M.,Lynch, D.,Farnaby, W.,Nakasone, M.,Zollman, D.,Ciulli, A. Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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