8RQC

Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2

8RQC の概要

• エントリーDOI: 10.2210/pdb8rqc/pdb
• 分子名称: Protein cereblon, DNA-binding protein Ikaros, ZINC ION, ... (5 entities in total)
• 機能のキーワード: e3 ligase, protac, tpd, molecular glue, targeted protein degradation, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84393.69

構造登録者

Furihata, H.,Kroupova, A.,Zollman, D.,Ciulli, A. (登録日: 2024-01-17, 公開日: 2024-09-25)

• 主引用文献: Kroupova, A.,Spiteri, V.,Furihata, H.,Darren, D.,Ramachandran, S.,Rutter, Z.,Chakraborti, S.,Haubrich, K.,Pethe, J.,Gonzales, D.,Wijaya, A.,Rodriguez-Rios, M.,Lynch, D.,Farnaby, W.,Nakasone, M.,Zollman, D.,Ciulli, A.; Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders; To Be Published,

実験手法

X-RAY DIFFRACTION (2.15 Å)