8RDS

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8i

This is a non-PDB format compatible entry.

Summary for 8RDS

• Entry DOI: 10.2210/pdb8rds/pdb
• Descriptor: Cereblon isoform 4, ZINC ION, (5~{S})-3-(2-methoxyphenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, ... (5 entities in total)
• Functional Keywords: cereblon, ubiquitination, e3, molecular glue, spiro-isoxazole, signaling protein
• Biological source: Magnetospirillum gryphiswaldense
• Total number of polymer chains: 3
• Total formula weight: 41950.47

Authors

Bischof, L.,Hartmann, M.D. (deposition date: 2023-12-08, release date: 2024-04-10)

• Primary citation: Shevalev, R.,Bischof, L.,Sapegin, A.,Bunev, A.,Olga, G.,Kantin, G.,Kalinin, S.,Hartmann, M.D.; Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.; Eur.J.Med.Chem., 270:116328-116328, 2024; PubMed: 38552426; DOI: 10.1016/j.ejmech.2024.116328

Experimental method

X-RAY DIFFRACTION (2 Å)