8R0J

Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a

Summary for 8R0J

• Entry DOI: 10.2210/pdb8r0j/pdb
• Descriptor: Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35, Bis-1,3-phenyl guanylhydrazon, ... (5 entities in total)
• Functional Keywords: complex, transport, recycling, ligand, protein transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 112714.90

Authors

Milani, M.,Fagnani, E. (deposition date: 2023-10-31, release date: 2024-03-27)

• Primary citation: Fagnani, E.,Boni, F.,Seneci, P.,Gornati, D.,Muzio, L.,Mastrangelo, E.,Milani, M.; Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface.; Comput Struct Biotechnol J, 23:1088-1093, 2024; PubMed: 38487369; DOI: 10.1016/j.csbj.2024.02.026

Experimental method

X-RAY DIFFRACTION (2.4 Å)