8QZQ

Single particle cryo-EM co-structure of E. coli AcrB with bound BDM91531 inhibitor

Summary for 8QZQ

• Entry DOI: 10.2210/pdb8qzq/pdb
• EMDB information: 18780
• Descriptor: Multidrug efflux pump subunit AcrB, [3-(3-chloranyl-2-piperazin-1-yl-quinolin-6-yl)phenyl]methanamine, [(2~{R})-1-[[(2~{R})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-undecanoyloxy-propan-2-yl] tricosanoate (3 entities in total)
• Functional Keywords: efflux pump inhibitor, transmembrane binding, antibiotic resistance, transport protein
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 3
• Total formula weight: 342099.42

Authors

Boernsen, C.,Mueller, R.T.,Pos, K.M.,Frangakis, A.S. (deposition date: 2023-10-29, release date: 2024-11-06)

• Primary citation: Boernsen, C.,Mueller, R.T.; Single particle cryo-EM co-structure of E. coli AcrB with bound BDM91531 inhibitor at 3.23 A resolution; To be published,

Experimental method

ELECTRON MICROSCOPY (3.23 Å)