8QZ2

Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61)

Summary for 8QZ2

• Entry DOI: 10.2210/pdb8qz2/pdb
• Descriptor: Potassium channel subfamily K member 10, Nanobody 61, POTASSIUM ION (3 entities in total)
• Functional Keywords: potassium ion channel, nanobody, membrane protein, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 75474.90

Authors

Baronina, A.,Pike, A.C.W.,Rodstrom, K.E.J.,Ang, J.,Bushell, S.R.,Chalk, R.,Mukhopadhyay, S.M.M.,Pardon, E.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.A.,Tucker, S.J.,Steyaert, J.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-26, release date: 2024-05-29)

• Primary citation: Rodstrom, K.E.J.,Cloake, A.,Sormann, J.,Baronina, A.,Smith, K.H.M.,Pike, A.C.W.,Ang, J.,Proks, P.,Schewe, M.,Holland-Kaye, I.,Bushell, S.R.,Elliott, J.,Pardon, E.,Baukrowitz, T.,Owens, R.J.,Newstead, S.,Steyaert, J.,Carpenter, E.P.,Tucker, S.J.; Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.; Nat Commun, 15:4173-4173, 2024; PubMed: 38755204; DOI: 10.1038/s41467-024-48536-2

Experimental method

X-RAY DIFFRACTION (3.5 Å)