8QQY
Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with JG165
Summary for 8QQY
Entry DOI | 10.2210/pdb8qqy/pdb |
Descriptor | Ephrin type-A receptor 2, 6-(4-fluoranyl-3-methoxy-phenyl)-13$l^{6}-thia-2,4,8,12,19-pentazatricyclo[12.3.1.1^{3,7}]nonadeca-1(18),3,5,7(19),14,16-hexaene 13,13-dioxide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | epha2, ephrin type-a receptor 2, inhibitor, macrocycle, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35699.19 |
Authors | Zhubi, R.,Gerninghaus, J.,Knapp, S.,Kraemer, A.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-06, release date: 2023-11-22, Last modification date: 2024-07-31) |
Primary citation | Kramer, A.,Tjaden, A.,Ndreshkjana, B.,Tredup, C.,Farin, H.F.,Knapp, S.,Janin, Y.L.,Muller, S. IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH) Curr Res Chem Biol, 2:100034-, 2022 Cited by DOI: 10.1016/j.crchbi.2022.100034PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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