8QE8

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate

Summary for 8QE8

• Entry DOI: 10.2210/pdb8qe8/pdb
• Related: 8QBN
• EMDB information: 18170 18171 18172 18173 18174 18175 18176 18177 18178 18316 18345
• Descriptor: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, WD repeat-containing protein 26, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ctlh, gid, nmnat1, ypel5, nad, nadh, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 333775.83

Authors

Chrustowicz, J.,Sherpa, D.,Schulman, B.A. (deposition date: 2023-08-30, release date: 2024-05-15, Last modification date: 2024-05-29)

• Primary citation: Gottemukkala, K.V.,Chrustowicz, J.,Sherpa, D.,Sepic, S.,Vu, D.T.,Karayel, O.,Papadopoulou, E.C.,Gross, A.,Schorpp, K.,von Gronau, S.,Hadian, K.,Murray, P.J.,Mann, M.,Schulman, B.A.,Alpi, A.F.; Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.; Mol.Cell, 84:1948-1963.e11, 2024; PubMed: 38759627; DOI: 10.1016/j.molcel.2024.04.014

Experimental method

ELECTRON MICROSCOPY (3.8 Å)