Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QE8

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000166	molecular_function	nucleotide binding
1	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
1	0000785	cellular_component	chromatin
1	0003824	molecular_function	catalytic activity
1	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0006163	biological_process	purine nucleotide metabolic process
1	0009058	biological_process	biosynthetic process
1	0009165	biological_process	nucleotide biosynthetic process
1	0009435	biological_process	NAD+ biosynthetic process
1	0016604	cellular_component	nuclear body
1	0016740	molecular_function	transferase activity
1	0016779	molecular_function	nucleotidyltransferase activity
1	0019363	biological_process	pyridine nucleotide biosynthetic process
1	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
1	0042802	molecular_function	identical protein binding
1	0045892	biological_process	negative regulation of DNA-templated transcription
1	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
1	1990966	biological_process	ATP generation from poly-ADP-D-ribose
2	0000166	molecular_function	nucleotide binding
2	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
2	0000785	cellular_component	chromatin
2	0003824	molecular_function	catalytic activity
2	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0006163	biological_process	purine nucleotide metabolic process
2	0009058	biological_process	biosynthetic process
2	0009165	biological_process	nucleotide biosynthetic process
2	0009435	biological_process	NAD+ biosynthetic process
2	0016604	cellular_component	nuclear body
2	0016740	molecular_function	transferase activity
2	0016779	molecular_function	nucleotidyltransferase activity
2	0019363	biological_process	pyridine nucleotide biosynthetic process
2	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
2	0042802	molecular_function	identical protein binding
2	0045892	biological_process	negative regulation of DNA-templated transcription
2	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
2	1990966	biological_process	ATP generation from poly-ADP-D-ribose
3	0000166	molecular_function	nucleotide binding
3	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
3	0000785	cellular_component	chromatin
3	0003824	molecular_function	catalytic activity
3	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0006163	biological_process	purine nucleotide metabolic process
3	0009058	biological_process	biosynthetic process
3	0009165	biological_process	nucleotide biosynthetic process
3	0009435	biological_process	NAD+ biosynthetic process
3	0016604	cellular_component	nuclear body
3	0016740	molecular_function	transferase activity
3	0016779	molecular_function	nucleotidyltransferase activity
3	0019363	biological_process	pyridine nucleotide biosynthetic process
3	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
3	0042802	molecular_function	identical protein binding
3	0045892	biological_process	negative regulation of DNA-templated transcription
3	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
3	1990966	biological_process	ATP generation from poly-ADP-D-ribose
4	0000166	molecular_function	nucleotide binding
4	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
4	0000785	cellular_component	chromatin
4	0003824	molecular_function	catalytic activity
4	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0006163	biological_process	purine nucleotide metabolic process
4	0009058	biological_process	biosynthetic process
4	0009165	biological_process	nucleotide biosynthetic process
4	0009435	biological_process	NAD+ biosynthetic process
4	0016604	cellular_component	nuclear body
4	0016740	molecular_function	transferase activity
4	0016779	molecular_function	nucleotidyltransferase activity
4	0019363	biological_process	pyridine nucleotide biosynthetic process
4	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
4	0042802	molecular_function	identical protein binding
4	0045892	biological_process	negative regulation of DNA-templated transcription
4	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
4	1990966	biological_process	ATP generation from poly-ADP-D-ribose
5	0000166	molecular_function	nucleotide binding
5	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
5	0000785	cellular_component	chromatin
5	0003824	molecular_function	catalytic activity
5	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0006163	biological_process	purine nucleotide metabolic process
5	0009058	biological_process	biosynthetic process
5	0009165	biological_process	nucleotide biosynthetic process
5	0009435	biological_process	NAD+ biosynthetic process
5	0016604	cellular_component	nuclear body
5	0016740	molecular_function	transferase activity
5	0016779	molecular_function	nucleotidyltransferase activity
5	0019363	biological_process	pyridine nucleotide biosynthetic process
5	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
5	0042802	molecular_function	identical protein binding
5	0045892	biological_process	negative regulation of DNA-templated transcription
5	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
5	1990966	biological_process	ATP generation from poly-ADP-D-ribose
6	0000166	molecular_function	nucleotide binding
6	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
6	0000785	cellular_component	chromatin
6	0003824	molecular_function	catalytic activity
6	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0006163	biological_process	purine nucleotide metabolic process
6	0009058	biological_process	biosynthetic process
6	0009165	biological_process	nucleotide biosynthetic process
6	0009435	biological_process	NAD+ biosynthetic process
6	0016604	cellular_component	nuclear body
6	0016740	molecular_function	transferase activity
6	0016779	molecular_function	nucleotidyltransferase activity
6	0019363	biological_process	pyridine nucleotide biosynthetic process
6	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
6	0042802	molecular_function	identical protein binding
6	0045892	biological_process	negative regulation of DNA-templated transcription
6	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
6	1990966	biological_process	ATP generation from poly-ADP-D-ribose
A	0000151	cellular_component	ubiquitin ligase complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0034657	cellular_component	GID complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0000151	cellular_component	ubiquitin ligase complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0034657	cellular_component	GID complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96T66","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"11788603","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	78
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11788603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96T66","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11959140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GZU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	80
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	84
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)