Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QE8

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to NMNAT1 substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
1	0000785	cellular_component	chromatin
1	0003824	molecular_function	catalytic activity
1	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0009058	biological_process	biosynthetic process
1	0009165	biological_process	nucleotide biosynthetic process
1	0009435	biological_process	NAD biosynthetic process
1	0009611	biological_process	response to wounding
1	0016604	cellular_component	nuclear body
1	0016779	molecular_function	nucleotidyltransferase activity
1	0019363	biological_process	pyridine nucleotide biosynthetic process
1	0042802	molecular_function	identical protein binding
1	0043410	biological_process	positive regulation of MAPK cascade
1	0043524	biological_process	negative regulation of neuron apoptotic process
1	0045892	biological_process	negative regulation of DNA-templated transcription
1	0070566	molecular_function	adenylyltransferase activity
1	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
1	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
1	1990966	biological_process	ATP generation from poly-ADP-D-ribose
2	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
2	0000785	cellular_component	chromatin
2	0003824	molecular_function	catalytic activity
2	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0009058	biological_process	biosynthetic process
2	0009165	biological_process	nucleotide biosynthetic process
2	0009435	biological_process	NAD biosynthetic process
2	0009611	biological_process	response to wounding
2	0016604	cellular_component	nuclear body
2	0016779	molecular_function	nucleotidyltransferase activity
2	0019363	biological_process	pyridine nucleotide biosynthetic process
2	0042802	molecular_function	identical protein binding
2	0043410	biological_process	positive regulation of MAPK cascade
2	0043524	biological_process	negative regulation of neuron apoptotic process
2	0045892	biological_process	negative regulation of DNA-templated transcription
2	0070566	molecular_function	adenylyltransferase activity
2	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
2	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
2	1990966	biological_process	ATP generation from poly-ADP-D-ribose
3	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
3	0000785	cellular_component	chromatin
3	0003824	molecular_function	catalytic activity
3	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0009058	biological_process	biosynthetic process
3	0009165	biological_process	nucleotide biosynthetic process
3	0009435	biological_process	NAD biosynthetic process
3	0009611	biological_process	response to wounding
3	0016604	cellular_component	nuclear body
3	0016779	molecular_function	nucleotidyltransferase activity
3	0019363	biological_process	pyridine nucleotide biosynthetic process
3	0042802	molecular_function	identical protein binding
3	0043410	biological_process	positive regulation of MAPK cascade
3	0043524	biological_process	negative regulation of neuron apoptotic process
3	0045892	biological_process	negative regulation of DNA-templated transcription
3	0070566	molecular_function	adenylyltransferase activity
3	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
3	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
3	1990966	biological_process	ATP generation from poly-ADP-D-ribose
4	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
4	0000785	cellular_component	chromatin
4	0003824	molecular_function	catalytic activity
4	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0009058	biological_process	biosynthetic process
4	0009165	biological_process	nucleotide biosynthetic process
4	0009435	biological_process	NAD biosynthetic process
4	0009611	biological_process	response to wounding
4	0016604	cellular_component	nuclear body
4	0016779	molecular_function	nucleotidyltransferase activity
4	0019363	biological_process	pyridine nucleotide biosynthetic process
4	0042802	molecular_function	identical protein binding
4	0043410	biological_process	positive regulation of MAPK cascade
4	0043524	biological_process	negative regulation of neuron apoptotic process
4	0045892	biological_process	negative regulation of DNA-templated transcription
4	0070566	molecular_function	adenylyltransferase activity
4	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
4	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
4	1990966	biological_process	ATP generation from poly-ADP-D-ribose
5	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
5	0000785	cellular_component	chromatin
5	0003824	molecular_function	catalytic activity
5	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0009058	biological_process	biosynthetic process
5	0009165	biological_process	nucleotide biosynthetic process
5	0009435	biological_process	NAD biosynthetic process
5	0009611	biological_process	response to wounding
5	0016604	cellular_component	nuclear body
5	0016779	molecular_function	nucleotidyltransferase activity
5	0019363	biological_process	pyridine nucleotide biosynthetic process
5	0042802	molecular_function	identical protein binding
5	0043410	biological_process	positive regulation of MAPK cascade
5	0043524	biological_process	negative regulation of neuron apoptotic process
5	0045892	biological_process	negative regulation of DNA-templated transcription
5	0070566	molecular_function	adenylyltransferase activity
5	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
5	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
5	1990966	biological_process	ATP generation from poly-ADP-D-ribose
6	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
6	0000785	cellular_component	chromatin
6	0003824	molecular_function	catalytic activity
6	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0009058	biological_process	biosynthetic process
6	0009165	biological_process	nucleotide biosynthetic process
6	0009435	biological_process	NAD biosynthetic process
6	0009611	biological_process	response to wounding
6	0016604	cellular_component	nuclear body
6	0016779	molecular_function	nucleotidyltransferase activity
6	0019363	biological_process	pyridine nucleotide biosynthetic process
6	0042802	molecular_function	identical protein binding
6	0043410	biological_process	positive regulation of MAPK cascade
6	0043524	biological_process	negative regulation of neuron apoptotic process
6	0045892	biological_process	negative regulation of DNA-templated transcription
6	0070566	molecular_function	adenylyltransferase activity
6	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
6	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
6	1990966	biological_process	ATP generation from poly-ADP-D-ribose
A	0000151	cellular_component	ubiquitin ligase complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0034657	cellular_component	GID complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0000151	cellular_component	ubiquitin ligase complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0034657	cellular_component	GID complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER121
4	LEU168
4	TRP169
4	GLU215
4	ASN219
5	GLY15
5	SER16
5	PHE17
5	MET23
5	LYS57
5	TRP92
B	SER121
5	THR95
5	GLY156
5	ASP158
5	LEU168
5	TRP169
5	GLU215
5	ASN219
6	GLY15
6	SER16
6	PHE17
4	PHE17
6	MET23
6	LYS57
6	TRP92
6	THR95
6	GLY156
6	ASP158
6	LEU168
6	TRP169
6	GLU215
6	ASN219
4	MET23
3	GLY15
3	SER16
3	PHE17
3	MET23
3	LYS57
3	TRP92
3	THR95
3	GLY156
3	ASP158
3	LEU168
4	LYS57
3	TRP169
3	GLU215
3	ASN219
2	GLY15
2	SER16
2	PHE17
2	MET23
2	LYS57
2	TRP92
2	THR95
4	TRP92
2	GLY156
2	ASP158
2	LEU168
2	TRP169
2	GLU215
2	ASN219
1	GLY15
1	SER16
1	PHE17
1	MET23
4	THR95
1	LYS57
1	TRP92
1	THR95
1	GLY156
1	ASP158
1	LEU168
1	TRP169
1	GLU215
1	ASN219
4	GLY156
4	ASP158

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER123
3	HIS24
3	LYS58
3	THR224
2	HIS24
2	LYS58
2	THR224
1	HIS24
1	LYS58
1	THR224
B	SER123
4	THR224
5	HIS24
5	LYS58
5	THR224
6	HIS24
6	LYS58
6	THR224

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11959140, ECO:0007744\|PDB:1GZU

Chain	Residue	Details
4	TYR55
5	TYR55
6	TYR55
3	TYR55
2	TYR55
1	TYR55

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
4	SER117
5	SER117
6	SER117
3	SER117
2	SER117
1	SER117

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
4	THR119
5	THR119
6	THR119
3	THR119
2	THR119
1	THR119

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)