8Q61

Co-crystal structure of human AKT2 with compound 3

Summary for 8Q61

• Entry DOI: 10.2210/pdb8q61/pdb
• Descriptor: RAC-beta serine/threonine-protein kinase, 6-[4-(1-azanyl-3-methyl-3-oxidanyl-cyclobutyl)phenyl]-7-phenyl-1-propyl-pyrido[2,3-b][1,4]oxazin-2-one, GLYCEROL, ... (6 entities in total)
• Functional Keywords: protein kinase inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 56990.57

Authors

Harrison, T.,Barker, O. (deposition date: 2023-08-10, release date: 2023-08-16)

• Primary citation: Page, N.,Wappett, M.,O'Dowd, C.R.,O'Rourke, M.,Gavory, G.,Zhang, L.,Rountree, J.S.S.,Jordan, L.,Barker, O.,Gibson, H.,Boyd, C.,Feutren-Burton, S.,McLean, E.,Trevitt, G.,Harrison, T.; Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.; Sci Rep, 12:15715-, 2022; PubMed: 36127435; DOI: 10.1172/JCI41680

Experimental method

X-RAY DIFFRACTION (2.32 Å)