8Q61
Co-crystal structure of human AKT2 with compound 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005938 | cellular_component | cell cortex |
| A | 0005978 | biological_process | glycogen biosynthetic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006417 | biological_process | regulation of translation |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0010748 | biological_process | negative regulation of long-chain fatty acid import across plasma membrane |
| A | 0010907 | biological_process | positive regulation of glucose metabolic process |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0032000 | biological_process | positive regulation of fatty acid beta-oxidation |
| A | 0032287 | biological_process | peripheral nervous system myelin maintenance |
| A | 0032587 | cellular_component | ruffle membrane |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0036211 | biological_process | protein modification process |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0045725 | biological_process | positive regulation of glycogen biosynthetic process |
| A | 0046326 | biological_process | positive regulation of glucose import |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060644 | biological_process | mammary gland epithelial cell differentiation |
| A | 0071486 | biological_process | cellular response to high light intensity |
| A | 0072659 | biological_process | protein localization to plasma membrane |
| A | 0090314 | biological_process | positive regulation of protein targeting to membrane |
| A | 0097473 | biological_process | retinal rod cell apoptotic process |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0140677 | molecular_function | molecular function activator activity |
| A | 2000147 | biological_process | positive regulation of cell motility |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 34 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVrekatgryyamkilrkevIIAK |
| Chain | Residue | Details |
| A | LEU158-LYS191 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDIKleNLML |
| Chain | Residue | Details |
| A | VAL271-LEU283 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP275 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU158 | |
| A | LYS181 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12434148 |
| Chain | Residue | Details |
| A | ASN280 | |
| A | ASP293 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER34 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER126 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:12434148, ECO:0000269|PubMed:15890450, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:9512493 |
| Chain | Residue | Details |
| A | THR309 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER447 | |
| A | SER478 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR451 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15890450, ECO:0000269|PubMed:20059950, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER474 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
| Chain | Residue | Details |
| A | SER128 | |
| A | SER131 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250 |
| Chain | Residue | Details |
| A | THR306 | |
| A | THR313 |
