8Q61
Co-crystal structure of human AKT2 with compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RAC-beta serine/threonine-protein kinase | polymer | 483 | 55974.8 | 1 | UniProt (P31751) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | |
| 2 | B (A) | 6-[4-(1-azanyl-3-methyl-3-oxidanyl-cyclobutyl)phenyl]-7-phenyl-1-propyl-pyrido[2,3-b][1,4]oxazin-2-one | non-polymer | 443.5 | 1 | Chemie (K06) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, E, F (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 5 | G (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | H (A) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 1 - 481 (UniProt: P31751)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Asp 2 | Asn 2 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55974.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1015.8 | |
| All* | Total formula weight | 56990.6 |
