8PB9

Cryo-EM structure of the c-di-GMP-bound FleQ-FleN master regulator complex from Pseudomonas aeruginosa

Summary for 8PB9

Entry DOI	10.2210/pdb8pb9/pdb
Related	8p53
EMDB information	17445 17581
Descriptor	Transcriptional regulator FleQ, Antiactivator FleN, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ... (4 entities in total)
Functional Keywords	biofilm formation, c-di-gmp signaling, second messengers, bacterial secretion, gene regulation, bebps
Biological source	Pseudomonas aeruginosa PAO1 More
Total number of polymer chains	5
Total formula weight	197698.47
Authors	Torres-Sanchez, L.T.,Krasteva, P.V. (deposition date: 2023-06-08, release date: 2023-12-13)
Primary citation	Torres-Sanchez, L.,Gery Sana, T.,Decossas, M.,Hashem, Y.,Krasteva, P.V. Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control. Proc.Natl.Acad.Sci.USA, 120:e2312276120-e2312276120, 2023 Cited by PubMed: 38051770 DOI: 10.1073/pnas.2312276120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation