8OZA

Human cathepsin L in complex with covalently bound CA-074 methyl ester

Summary for 8OZA

Entry DOI	10.2210/pdb8oza/pdb
Related	8A4V 8A4X 8C77
Descriptor	Cathepsin L, methyl (2S)-1-[(2S,3S)-3-methyl-2-[[(3S)-3-oxidanyl-4-oxidanylidene-4-(propylamino)butanoyl]amino]pentanoyl]pyrrolidine-2-carboxylate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	cystein protease, drug target, lysosome, epoxide, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	99116.63
Authors	Falke, S.,Lieske, J.,Guenther, S.,Ewert, W.,Reinke, P.Y.A.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2023-05-08, release date: 2023-07-05, Last modification date: 2024-05-22)
Primary citation	Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165 DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation