8A4X

Crystal structure of human Cathepsin L with covalently bound Calpain inhibitor III

Summary for 8A4X

• Entry DOI: 10.2210/pdb8a4x/pdb
• Related: 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W
• Descriptor: Cathepsin L, (phenylmethyl) N-[(2S)-3-methyl-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]carbamate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 99836.48

Authors

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-06-13, release date: 2023-07-05, Last modification date: 2024-02-07)

• Primary citation: Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A.; Structural elucidation of antiviral cathepsin L inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)