8A4W
Crystal structure of human cathepsin L with covalently bound Cathepsin L inhibitor IV
Summary for 8A4W
Entry DOI | 10.2210/pdb8a4w/pdb |
Related | 7ZS7 7ZVF 7ZXA 8A4U 8A4V |
Descriptor | Cathepsin L, N-(1-naphthylsulfonyl)-(L)-isoleucyl-(L)-tryptophanol, DI(HYDROXYETHYL)ETHER, ... (8 entities in total) |
Functional Keywords | cystein protease, drug target, lysosome, virus cell entry, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 99905.95 |
Authors | Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-06-13, release date: 2023-07-05, Last modification date: 2024-02-07) |
Primary citation | Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. Structural elucidation of antiviral cathepsin L inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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