8OZA
Human cathepsin L in complex with covalently bound CA-074 methyl ester
Summary for 8OZA
Entry DOI | 10.2210/pdb8oza/pdb |
Related | 8A4V 8A4X 8C77 |
Descriptor | Cathepsin L, methyl (2S)-1-[(2S,3S)-3-methyl-2-[[(3S)-3-oxidanyl-4-oxidanylidene-4-(propylamino)butanoyl]amino]pentanoyl]pyrrolidine-2-carboxylate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | cystein protease, drug target, lysosome, epoxide, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 99116.63 |
Authors | Falke, S.,Lieske, J.,Guenther, S.,Ewert, W.,Reinke, P.Y.A.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2023-05-08, release date: 2023-07-05, Last modification date: 2024-05-22) |
Primary citation | Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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