8OMV

Crystal structure of the constitutively active S117E/S181E mutant of human IKK2

Summary for 8OMV

• Entry DOI: 10.2210/pdb8omv/pdb
• Descriptor: Inhibitor of nuclear factor kappa-B kinase subunit beta (1 entity in total)
• Functional Keywords: ikk, nf-kappab, ikba, docking, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 5
• Total formula weight: 387043.91

Authors

McEwen, A.G.,Li, C.,Moro, S.,Poussin-Courmontagne, P.,Zanier, K. (deposition date: 2023-03-31, release date: 2024-04-10)

• Primary citation: Li, C.,Moro, S.,Shastak, K.,O'Reily, F.,Donzeau, M.,Graziadei, A.,McEwen, A.G.,Poussin-Courmontagne, P.,Bachelart, T.,Fiskin, M.,Berrodier, N.,Orfanoudakis, G.,Poterszman, A.,Torbeev, V.,Rappsilber, J.,Davy, N.,Chariot, A.,Zanier, K.; A novel YDD(phi)X(phi) linear motif mediates docking of IKK catalytic dimers to NF-kappaB substrates: structural and functional insights; To be published,

Experimental method

X-RAY DIFFRACTION (4.16 Å)