8OMV

Crystal structure of the constitutively active S117E/S181E mutant of human IKK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Inhibitor of nuclear factor kappa-B kinase subunit beta	polymer	671	77408.8	5	UniProt (O14920) Pfam (PF00069) Pfam (PF18397) In PDB	Homo sapiens (human)	I-kappa-B-kinase beta,IKK-B,IKK-beta,IkBKB,I-kappa-B kinase 2,IKK2,Nuclear factor NF-kappa-B inhibitor kinase beta,NFKBIKB,Serine/threonine protein kinase IKBKB

Sequence modifications

A, B, C, D, E: 1 - 669 (UniProt: O14920)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag
Glu 177	Ser 177	engineered mutation
Glu 181	Ser 181	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	387043.9
All*	Total formula weight	387043.9

*Water molecules are not included.