8OMV
Crystal structure of the constitutively active S117E/S181E mutant of human IKK2
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNIVL |
| Chain | Residue | Details |
| A | ILE141-LEU153 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP145 | |
| B | ASP145 | |
| C | ASP145 | |
| D | ASP145 | |
| E | ASP145 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU21 | |
| E | LYS44 | |
| A | LYS44 | |
| B | LEU21 | |
| B | LYS44 | |
| C | LEU21 | |
| C | LYS44 | |
| D | LEU21 | |
| D | LYS44 | |
| E | LEU21 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine; by TBK1 and PKC/PRKCZ => ECO:0000269|PubMed:10022904, ECO:0000269|PubMed:10195894, ECO:0000269|PubMed:10783893 |
| Chain | Residue | Details |
| A | GLU177 | |
| B | GLU177 | |
| C | GLU177 | |
| D | GLU177 | |
| E | GLU177 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:15184672 |
| Chain | Residue | Details |
| A | CYS179 | |
| B | CYS179 | |
| C | CYS179 | |
| D | CYS179 | |
| E | CYS179 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:17116858 |
| Chain | Residue | Details |
| A | THR180 | |
| B | THR180 | |
| C | THR180 | |
| D | THR180 | |
| E | THR180 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1 => ECO:0000269|PubMed:10022904, ECO:0000269|PubMed:10195894, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:16207722 |
| Chain | Residue | Details |
| A | GLU181 | |
| B | GLU181 | |
| C | GLU181 | |
| D | GLU181 | |
| E | GLU181 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | MOD_RES: Hydroxyproline => ECO:0000269|PubMed:17114296 |
| Chain | Residue | Details |
| A | PRO191 | |
| B | PRO191 | |
| C | PRO191 | |
| D | PRO191 | |
| E | PRO191 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16267042 |
| Chain | Residue | Details |
| A | LYS163 | |
| B | LYS163 | |
| C | LYS163 | |
| D | LYS163 | |
| E | LYS163 |
