8KG5

Prefusion RSV F Bound to Lonafarnib and D25 Fab

8KG5 の概要

• エントリーDOI: 10.2210/pdb8kg5/pdb
• EMDBエントリー: 37210
• 分子名称: Fusion glycoprotein F0,Fibritin, D25 heavy chain, D25 light chain, ... (4 entities in total)
• 機能のキーワード: respiratory syncytial virus, f protein, lonafarnib, viral protein/immune system, viral protein-immune system complex
• 由来する生物種: Human respiratory syncytial virus A (strain A2); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 243338.77

構造登録者

Yang, Q.,Xue, B.,Liu, F.,Peng, W.,Chen, X. (登録日: 2023-08-17, 公開日: 2024-06-19)

• 主引用文献: Yang, Q.,Xue, B.,Liu, F.,Lu, Y.,Tang, J.,Yan, M.,Wu, Q.,Chen, R.,Zhou, A.,Liu, L.,Liu, J.,Qu, C.,Wu, Q.,Fu, M.,Zhong, J.,Dong, J.,Chen, S.,Wang, F.,Zhou, Y.,Zheng, J.,Peng, W.,Shang, J.,Chen, X.; Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.; Signal Transduct Target Ther, 9:144-144, 2024; PubMed: 38853183; DOI: 10.1038/s41392-024-01858-5

実験手法

ELECTRON MICROSCOPY (3.17 Å)