8JYR

Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I

Summary for 8JYR

• Entry DOI: 10.2210/pdb8jyr/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, H2Mab-119 VH-CH1, H2Mab-119 light chain, ... (5 entities in total)
• Functional Keywords: her2, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 70769.13

Authors

Arimori, T.,Takagi, J. (deposition date: 2023-07-03, release date: 2024-03-13, Last modification date: 2024-03-27)

• Primary citation: Arimori, T.,Mihara, E.,Suzuki, H.,Ohishi, T.,Tanaka, T.,Kaneko, M.K.,Takagi, J.,Kato, Y.; Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies.; Structure, 2024; PubMed: 38460519; DOI: 10.1016/j.str.2024.02.007

Experimental method

X-RAY DIFFRACTION (1.69 Å)