8JYR
Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor tyrosine-protein kinase erbB-2 | polymer | 202 | 22726.8 | 1 | UniProt (P04626) Pfam (PF01030) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | B (H) | H2Mab-119 VH-CH1 | polymer | 222 | 23821.7 | 1 | Mus musculus | ||
| 3 | C (L) | H2Mab-119 light chain | polymer | 218 | 23999.4 | 1 | Mus musculus | ||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 475 | Chemie (HOH) |
Sequence modifications
A: 23 - 216 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Ala 217 | - | expression tag |
| Ser 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
| His 223 | - | expression tag |
| His 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70547.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 70769.1 |
