8J9V

Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02aDNA and etoposide (EDI-1)

Summary for 8J9V

• Entry DOI: 10.2210/pdb8j9v/pdb
• EMDB information: 36116
• Descriptor: DNA topoisomerase 2, DNA (5'-D(*GP*AP*GP*GP*TP*AP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*CP*GP*CP*CP*TP*AP*CP*AP*TP*AP*CP*CP*TP*C)-3'), ... (5 entities in total)
• Functional Keywords: topoisomerase, asfv, inhibitor, viral protein, isomerase-dna complex, isomerase/dna
• Biological source: African swine fever virus; More
• Total number of polymer chains: 6
• Total formula weight: 292430.82

Authors

Chang, C.-W.,Tsai, M.-D. (deposition date: 2023-05-05, release date: 2024-02-07, Last modification date: 2024-04-17)

• Primary citation: Chang, C.M.,Wang, S.C.,Wang, C.H.,Pang, A.H.,Yang, C.H.,Chang, Y.K.,Wu, W.J.,Tsai, M.D.; A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase.; Commun Chem, 7:45-45, 2024; PubMed: 38418525; DOI: 10.1038/s42004-024-01129-y

Experimental method

ELECTRON MICROSCOPY (2.71 Å)