8IZC
Human CK1 Delta Kinase structure bound to Inhibitor
Summary for 8IZC
Entry DOI | 10.2210/pdb8izc/pdb |
Descriptor | Casein kinase I isoform delta, SULFATE ION, ~{N}5-~{tert}-butyl-2-(3-chloranyl-4-fluoranyl-phenyl)-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide, ... (4 entities in total) |
Functional Keywords | ck1, kinase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 68882.14 |
Authors | |
Primary citation | Velaparthi, U.,Selvakumar, K. The Discovery of BMS-986164, a Potent, Selective and Orally Efficacious CK1d/e/a Inhibitor from Pyrazolo-Piperazine Chemotype To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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