8HUB

AMP deaminase 2 in complex with an inhibitor

Summary for 8HUB

Entry DOI	10.2210/pdb8hub/pdb
Related	8HU6
Descriptor	AMP deaminase 2, ZINC ION, 3,3-dimethyl-4-(phenylmethyl)-2~{H}-quinoxaline-1-carboxamide (3 entities in total)
Functional Keywords	complex, deaminase, amp, imp, energy metabolism, inhibitor, allosteric inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	316158.36
Authors	Adachi, T.,Doi, S. (deposition date: 2022-12-23, release date: 2023-01-18, Last modification date: 2024-05-29)
Primary citation	Kitao, Y.,Saito, T.,Watanabe, S.,Ohe, Y.,Takahashi, K.,Akaki, T.,Adachi, T.,Doi, S.,Yamanaka, K.,Murai, Y.,Oba, M.,Suzuki, T. The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action. Bioorg.Med.Chem.Lett., 80:129110-129110, 2023 Cited by PubMed: 36563792 DOI: 10.1016/j.bmcl.2022.129110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation