8HU6

AMP deaminase 2 in complex with AMP

Summary for 8HU6

Entry DOI	10.2210/pdb8hu6/pdb
Descriptor	AMP deaminase 2, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	complex, deaminase, amp, imp, energy metabolism, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	316003.70
Authors	Adachi, T.,Doi, S. (deposition date: 2022-12-22, release date: 2023-01-18, Last modification date: 2023-02-15)
Primary citation	Kitao, Y.,Saito, T.,Watanabe, S.,Ohe, Y.,Takahashi, K.,Akaki, T.,Adachi, T.,Doi, S.,Yamanaka, K.,Murai, Y.,Oba, M.,Suzuki, T. The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action. Bioorg.Med.Chem.Lett., 80:129110-129110, 2023 Cited by PubMed: 36563792 DOI: 10.1016/j.bmcl.2022.129110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation