8HOI

Crystal structure of Bcl-2 D103Y in complex with sonrotoclax

Summary for 8HOI

• Entry DOI: 10.2210/pdb8hoi/pdb
• Descriptor: Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: inhibitor, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 79703.10

Authors

Liu, J.,Xu, M.,Feng, Y.,Hong, Y.,Liu, Y. (deposition date: 2022-12-10, release date: 2024-01-17, Last modification date: 2024-05-15)

• Primary citation: Liu, J.,Li, S.,Wang, Q.,Feng, Y.,Xing, H.,Yang, X.,Guo, Y.,Guo, Y.,Sun, H.,Liu, X.,Yang, S.,Mei, Z.,Zhu, Y.,Cheng, Z.,Chen, S.,Xu, M.,Zhang, W.,Wan, N.,Wang, J.,Ma, Y.,Zhang, S.,Luan, X.,Xu, A.,Li, L.,Wang, H.,Yang, X.,Hong, Y.,Xue, H.,Yuan, X.,Hu, N.,Song, X.,Wang, Z.,Liu, X.,Wang, L.,Liu, Y.; Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.; Blood, 143:1825-1836, 2024; PubMed: 38211332; DOI: 10.1182/blood.2023019706

Experimental method

X-RAY DIFFRACTION (2.25 Å)