8HOI

Crystal structure of Bcl-2 D103Y in complex with sonrotoclax

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU137-GLY155

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP188-VAL199

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site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP10-TRP30

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Cleavage; by caspase-3

Chain	Residue	Details
A	ASP75
B	ASP75
C	ASP75
D	ASP75

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	ARG110
B	ARG110
C	ARG110
D	ARG110

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	ASP111
B	ASP111
C	ASP111
D	ASP111

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	GLY128
B	GLY128
C	GLY128
D	GLY128

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