8HOI
Crystal structure of Bcl-2 D103Y in complex with sonrotoclax
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Apoptosis regulator Bcl-2 | polymer | 162 | 19024.2 | 4 | Pfam (PF02180) Pfam (PF00452) UniProt (by SIFTS) (P10415) In PDB | Homo sapiens (human) | |
| 2 | A, B, C, D | ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | non-polymer | 890.1 | 4 | Chemie (98I) | |||
| 3 | B | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 4 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76096.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3606.4 | |
| All* | Total formula weight | 79703.1 |
