8GZN

IgM-var2CSA complex

Summary for 8GZN

• Entry DOI: 10.2210/pdb8gzn/pdb
• EMDB information: 34399
• Descriptor: Immunoglobulin heavy constant mu, Erythrocyte membrane protein 1, Immunoglobulin J chain (3 entities in total)
• Functional Keywords: var2csa, igm, placental malaria, p.falciparum, cell adhesion, cell adhesion-immune system complex, cell adhesion/immune system
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 13
• Total formula weight: 1132409.90

Authors

Akhouri, R.R.,Goel, S.,Skoglund, U. (deposition date: 2022-09-27, release date: 2023-10-25)

• Primary citation: Akhouri, R.R.,Goel, S.,Skoglund, U.; Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A.; Nat Commun, 14:6391-6391, 2023; PubMed: 37828011; DOI: 10.1038/s41467-023-41838-x

Experimental method

ELECTRON MICROSCOPY (3.6 Å)