8GZN

IgM-var2CSA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0003697	molecular_function	single-stranded DNA binding
A	0003823	molecular_function	antigen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006958	biological_process	complement activation, classical pathway
A	0009986	cellular_component	cell surface
A	0019731	biological_process	antibacterial humoral response
A	0019814	cellular_component	immunoglobulin complex
A	0031210	molecular_function	phosphatidylcholine binding
A	0034987	molecular_function	immunoglobulin receptor binding
A	0042571	cellular_component	immunoglobulin complex, circulating
A	0042834	molecular_function	peptidoglycan binding
A	0045087	biological_process	innate immune response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050853	biological_process	B cell receptor signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0071753	cellular_component	IgM immunoglobulin complex
A	0071756	cellular_component	pentameric IgM immunoglobulin complex
A	0071757	cellular_component	hexameric IgM immunoglobulin complex
A	0072562	cellular_component	blood microparticle
B	0002250	biological_process	adaptive immune response
B	0003697	molecular_function	single-stranded DNA binding
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006958	biological_process	complement activation, classical pathway
B	0009986	cellular_component	cell surface
B	0019731	biological_process	antibacterial humoral response
B	0019814	cellular_component	immunoglobulin complex
B	0031210	molecular_function	phosphatidylcholine binding
B	0034987	molecular_function	immunoglobulin receptor binding
B	0042571	cellular_component	immunoglobulin complex, circulating
B	0042834	molecular_function	peptidoglycan binding
B	0045087	biological_process	innate immune response
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050853	biological_process	B cell receptor signaling pathway
B	0070062	cellular_component	extracellular exosome
B	0071753	cellular_component	IgM immunoglobulin complex
B	0071756	cellular_component	pentameric IgM immunoglobulin complex
B	0071757	cellular_component	hexameric IgM immunoglobulin complex
B	0072562	cellular_component	blood microparticle
C	0002250	biological_process	adaptive immune response
C	0003697	molecular_function	single-stranded DNA binding
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006958	biological_process	complement activation, classical pathway
C	0009986	cellular_component	cell surface
C	0019731	biological_process	antibacterial humoral response
C	0019814	cellular_component	immunoglobulin complex
C	0031210	molecular_function	phosphatidylcholine binding
C	0034987	molecular_function	immunoglobulin receptor binding
C	0042571	cellular_component	immunoglobulin complex, circulating
C	0042834	molecular_function	peptidoglycan binding
C	0045087	biological_process	innate immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071753	cellular_component	IgM immunoglobulin complex
C	0071756	cellular_component	pentameric IgM immunoglobulin complex
C	0071757	cellular_component	hexameric IgM immunoglobulin complex
C	0072562	cellular_component	blood microparticle
D	0002250	biological_process	adaptive immune response
D	0003697	molecular_function	single-stranded DNA binding
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006958	biological_process	complement activation, classical pathway
D	0009986	cellular_component	cell surface
D	0019731	biological_process	antibacterial humoral response
D	0019814	cellular_component	immunoglobulin complex
D	0031210	molecular_function	phosphatidylcholine binding
D	0034987	molecular_function	immunoglobulin receptor binding
D	0042571	cellular_component	immunoglobulin complex, circulating
D	0042834	molecular_function	peptidoglycan binding
D	0045087	biological_process	innate immune response
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071753	cellular_component	IgM immunoglobulin complex
D	0071756	cellular_component	pentameric IgM immunoglobulin complex
D	0071757	cellular_component	hexameric IgM immunoglobulin complex
D	0072562	cellular_component	blood microparticle
E	0002250	biological_process	adaptive immune response
E	0003697	molecular_function	single-stranded DNA binding
E	0003823	molecular_function	antigen binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005886	cellular_component	plasma membrane
E	0006958	biological_process	complement activation, classical pathway
E	0009986	cellular_component	cell surface
E	0019731	biological_process	antibacterial humoral response
E	0019814	cellular_component	immunoglobulin complex
E	0031210	molecular_function	phosphatidylcholine binding
E	0034987	molecular_function	immunoglobulin receptor binding
E	0042571	cellular_component	immunoglobulin complex, circulating
E	0042834	molecular_function	peptidoglycan binding
E	0045087	biological_process	innate immune response
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050853	biological_process	B cell receptor signaling pathway
E	0070062	cellular_component	extracellular exosome
E	0071753	cellular_component	IgM immunoglobulin complex
E	0071756	cellular_component	pentameric IgM immunoglobulin complex
E	0071757	cellular_component	hexameric IgM immunoglobulin complex
E	0072562	cellular_component	blood microparticle
F	0002250	biological_process	adaptive immune response
F	0003697	molecular_function	single-stranded DNA binding
F	0003823	molecular_function	antigen binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005886	cellular_component	plasma membrane
F	0006958	biological_process	complement activation, classical pathway
F	0009986	cellular_component	cell surface
F	0019731	biological_process	antibacterial humoral response
F	0019814	cellular_component	immunoglobulin complex
F	0031210	molecular_function	phosphatidylcholine binding
F	0034987	molecular_function	immunoglobulin receptor binding
F	0042571	cellular_component	immunoglobulin complex, circulating
F	0042834	molecular_function	peptidoglycan binding
F	0045087	biological_process	innate immune response
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050853	biological_process	B cell receptor signaling pathway
F	0070062	cellular_component	extracellular exosome
F	0071753	cellular_component	IgM immunoglobulin complex
F	0071756	cellular_component	pentameric IgM immunoglobulin complex
F	0071757	cellular_component	hexameric IgM immunoglobulin complex
F	0072562	cellular_component	blood microparticle
G	0002250	biological_process	adaptive immune response
G	0003697	molecular_function	single-stranded DNA binding
G	0003823	molecular_function	antigen binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006958	biological_process	complement activation, classical pathway
G	0009986	cellular_component	cell surface
G	0019731	biological_process	antibacterial humoral response
G	0019814	cellular_component	immunoglobulin complex
G	0031210	molecular_function	phosphatidylcholine binding
G	0034987	molecular_function	immunoglobulin receptor binding
G	0042571	cellular_component	immunoglobulin complex, circulating
G	0042834	molecular_function	peptidoglycan binding
G	0045087	biological_process	innate immune response
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050853	biological_process	B cell receptor signaling pathway
G	0070062	cellular_component	extracellular exosome
G	0071753	cellular_component	IgM immunoglobulin complex
G	0071756	cellular_component	pentameric IgM immunoglobulin complex
G	0071757	cellular_component	hexameric IgM immunoglobulin complex
G	0072562	cellular_component	blood microparticle
H	0002250	biological_process	adaptive immune response
H	0003697	molecular_function	single-stranded DNA binding
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0006958	biological_process	complement activation, classical pathway
H	0009986	cellular_component	cell surface
H	0019731	biological_process	antibacterial humoral response
H	0019814	cellular_component	immunoglobulin complex
H	0031210	molecular_function	phosphatidylcholine binding
H	0034987	molecular_function	immunoglobulin receptor binding
H	0042571	cellular_component	immunoglobulin complex, circulating
H	0042834	molecular_function	peptidoglycan binding
H	0045087	biological_process	innate immune response
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050853	biological_process	B cell receptor signaling pathway
H	0070062	cellular_component	extracellular exosome
H	0071753	cellular_component	IgM immunoglobulin complex
H	0071756	cellular_component	pentameric IgM immunoglobulin complex
H	0071757	cellular_component	hexameric IgM immunoglobulin complex
H	0072562	cellular_component	blood microparticle
I	0016020	cellular_component	membrane
I	0046789	molecular_function	host cell surface receptor binding
J	0002250	biological_process	adaptive immune response
J	0003094	biological_process	glomerular filtration
J	0003697	molecular_function	single-stranded DNA binding
J	0003823	molecular_function	antigen binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006955	biological_process	immune response
J	0006959	biological_process	humoral immune response
J	0019731	biological_process	antibacterial humoral response
J	0019862	molecular_function	IgA binding
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031210	molecular_function	phosphatidylcholine binding
J	0034987	molecular_function	immunoglobulin receptor binding
J	0042803	molecular_function	protein homodimerization activity
J	0042834	molecular_function	peptidoglycan binding
J	0045087	biological_process	innate immune response
J	0060267	biological_process	positive regulation of respiratory burst
J	0065003	biological_process	protein-containing complex assembly
J	0070062	cellular_component	extracellular exosome
J	0071748	cellular_component	monomeric IgA immunoglobulin complex
J	0071750	cellular_component	dimeric IgA immunoglobulin complex
J	0071751	cellular_component	secretory IgA immunoglobulin complex
J	0071752	cellular_component	secretory dimeric IgA immunoglobulin complex
J	0071756	cellular_component	pentameric IgM immunoglobulin complex
J	0071757	cellular_component	hexameric IgM immunoglobulin complex
J	0072562	cellular_component	blood microparticle
K	0002250	biological_process	adaptive immune response
K	0003697	molecular_function	single-stranded DNA binding
K	0003823	molecular_function	antigen binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0006958	biological_process	complement activation, classical pathway
K	0009986	cellular_component	cell surface
K	0019731	biological_process	antibacterial humoral response
K	0019814	cellular_component	immunoglobulin complex
K	0031210	molecular_function	phosphatidylcholine binding
K	0034987	molecular_function	immunoglobulin receptor binding
K	0042571	cellular_component	immunoglobulin complex, circulating
K	0042834	molecular_function	peptidoglycan binding
K	0045087	biological_process	innate immune response
K	0050829	biological_process	defense response to Gram-negative bacterium
K	0050853	biological_process	B cell receptor signaling pathway
K	0070062	cellular_component	extracellular exosome
K	0071753	cellular_component	IgM immunoglobulin complex
K	0071756	cellular_component	pentameric IgM immunoglobulin complex
K	0071757	cellular_component	hexameric IgM immunoglobulin complex
K	0072562	cellular_component	blood microparticle
L	0002250	biological_process	adaptive immune response
L	0003697	molecular_function	single-stranded DNA binding
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006958	biological_process	complement activation, classical pathway
L	0009986	cellular_component	cell surface
L	0019731	biological_process	antibacterial humoral response
L	0019814	cellular_component	immunoglobulin complex
L	0031210	molecular_function	phosphatidylcholine binding
L	0034987	molecular_function	immunoglobulin receptor binding
L	0042571	cellular_component	immunoglobulin complex, circulating
L	0042834	molecular_function	peptidoglycan binding
L	0045087	biological_process	innate immune response
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071753	cellular_component	IgM immunoglobulin complex
L	0071756	cellular_component	pentameric IgM immunoglobulin complex
L	0071757	cellular_component	hexameric IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
M	0016020	cellular_component	membrane
M	0046789	molecular_function	host cell surface receptor binding

Functional Information from PROSITE/UniProt

site_id	PS00268
Number of Residues	11
Details	CECROPIN Cecropin family signature. WskKYIKKLEN

Chain	Residue	Details
I	TRP1605-ASN1615

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCRVDH

Chain	Residue	Details
A	PHE318-HIS324
A	PHE424-HIS430
A	TYR534-HIS540

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218

Chain	Residue	Details
J	ASN48
L	GLY124-GLY573
B	GLY124-GLY573
C	GLY124-GLY573
D	GLY124-GLY573
E	GLY124-GLY573
F	GLY124-GLY573
G	GLY124-GLY573
H	GLY124-GLY573
K	GLY124-GLY573

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16422668, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:2AGJ

Chain	Residue	Details
A	ASN169
L	ASN169
B	ASN169
C	ASN169
D	ASN169
E	ASN169
F	ASN169
G	ASN169
H	ASN169
K	ASN169

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:35981043, ECO:0007744|PDB:7XQ8

Chain	Residue	Details
A	ASN332
L	ASN332
B	ASN332
C	ASN332
D	ASN332
E	ASN332
F	ASN332
G	ASN332
H	ASN332
K	ASN332

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:35981043, ECO:0000269|PubMed:4742735, ECO:0007744|PDB:7XQ8

Chain	Residue	Details
A	ASN395
L	ASN395
B	ASN395
C	ASN395
D	ASN395
E	ASN395
F	ASN395
G	ASN395
H	ASN395
K	ASN395

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:35981043, ECO:0000269|PubMed:4742735, ECO:0007744|PDB:7XQ8

Chain	Residue	Details
A	ASN402
L	ASN402
B	ASN402
C	ASN402
D	ASN402
E	ASN402
F	ASN402
G	ASN402
H	ASN402
K	ASN402

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